Clarithromycin is inactive against Mycobacterium tuberculosis
نویسندگان
چکیده
منابع مشابه
In vitro synergy between linezolid and clarithromycin against Mycobacterium tuberculosis.
Approximately 3% of new tuberculosis cases worldwide represent multidrug-resistant tuberculosis (MDRTB) [1]. In these MDR-TB cases, resistance of Mycobacterium tuberculosis to the otherwise effective rifampicin and isoniazid forces clinicians to diverge to other antimicrobial agents. Such treatment options include the World Health Organization (WHO) group 5 drugs linezolid and clarithromycin [1...
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The rise of multidrug-resistant Mycobacterium tuberculosis has complicated therapy for tuberculosis and led us to search for a potentially active combination of drugs against these strains. The susceptibilities of 12 strains of multidrug-resistant M. tuberculosis to standard antituberculous drugs (isoniazid, rifampin, ethambutol, and pyrazinamide), clarithromycin, and its metabolite, 14-hydroxy...
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Resistance to clarithromycin in breakthrough Mycobacterium avium complex (MAC) isolates typically occurs 3 to 4 months after the initiation of monotherapy in bacteremic AIDS patients. It has been suggested that continuation of clarithromycin therapy still results in clinical and microbiological improvement. To study this paradox, C57BL/6 beige mice were infected with a clarithromycin-resistant ...
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We identified a series of novel 7-phenyl benzoxaborole compounds with activity against Mycobacterium tuberculosis. Compounds had a range of activity with inhibitory concentrations (IC90) as low as 5.1 μM and no cytotoxicity against eukaryotic cells (IC50 > 50 μM). Compounds were active against intracellular mycobacteria cultured in THP-1 macrophages. We isolated and characterized resistant muta...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1995
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.39.12.2827